Peptidomimetics in Organic and Medicinal Chemistry: The Art of Transforming Peptides in Drugs

Peptidomimetics in Organic and Medicinal Chemistry: The Art of Transforming Peptides in Drugs Front Cover
0 Reviews
2014-04-07
308 pages

Book Description

A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands.

Peptidomimetics in Organic and Medicinal outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery.

Book Details

  • Title: Peptidomimetics in Organic and Medicinal Chemistry: The Art of Transforming Peptides in Drugs
  • Author: ,
  • Length: 308 pages
  • Edition: 1
  • Language: English
  • Publisher:
  • Publication Date: 2014-04-07
  • ISBN-10: 1119950600
  • ISBN-13: 9781119950608
File HostFree Download LinkFormatSize (MB)Upload Date
NitroFlare Click to downloadTrue PDF9.603/11/2019
UsersCloud Click to downloadTrue PDF9.603/11/2019
How to Download? Report Dead Links & Get a Copy

Leave a Reply